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Biology professor and student publish paper on fly research

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October 11, 2016

Dr. Jacob Kagey, associate professor in biology, and Ashley Cosenza ’16 in biology publish a paper in the Advances in Bioscience and Biotechnology.

Dr. Jacob KageyThe article, The Mapping and Characterization of Cruella (Cru), a Novel Allele of Capping Protein α (Cpa), Identified from a Conditional Screen for Negative Regulators of Cell Growth and Cell Division, reports on cell growth and division of chromosomes in flies.

The research is part of a larger project working to identify new genes that regulate the cell cycle and cell division in fruit flies, two processes commonly disrupted during human cancer development.

An understanding of how genes function in simple model organisms can useful in understanding how the homologous genes may contribute to human disease.

In the study, they found that the mutant Cruella (so named due to the black pigmented nature of the mutant tissue juxtaposed to the white pigment of the wild type tissue) is a mutant in the gene Capping Protein Alpha.

Cells with this mutations have improper localization of different proteins and signaling molecules.

Cosenza graduated earlier this year in the Biology Honors program.  She successfully defended her Honors thesis on this topic.

The article is published in the Advances in Bioscience and Biotechnology (ABB), Vol.7 No. 10, 2016.  The full text of the article is available.

Congratulations to Dr. Kagey and Ashley!

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